Bill Hader

Flint Lockwood (voice)

Anna Faris

Sam Sparks (voice)

James Caan

Tim Lockwood (voice)

Andy Samberg

"Baby" Brent (voice)

Bruce Campbell

Mayor Shelbourne (voice)

Mr. T

Earl Devereaux (voice)

Bobb'e J. Thompson

Cal Devereaux (voice)

Benjamin Bratt

Manny (voice)

Neil Patrick Harris

Steve (voice)

Al Roker

Patrick Patrickson (voice)

Lauren Graham

Fran Lockwood (voice)

Will Forte

Joe Towne (voice)