Sandra Bullock

Scarlet Overkill (voice)

Jon Hamm

Herb Overkill (voice)

Michael Keaton

Walter Nelson (voice)

Allison Janney

Madge Nelson (voice)

Steve Coogan

Professor Flux / Tower Guard (voice)

Jennifer Saunders

Reine Elizabeth II (voice)

Geoffrey Rush

Narrator (voice)

Steve Carell

Young Gru (voice)

Pierre Coffin

The Minions (voice)

Katy Mixon

Tina (voice)

Michael Beattie

VNC Announcer / Walter Jr. (voice)

Hiroyuki Sanada

Sumo Villain (voice)