James Marsden

Tim (voice)

Alec Baldwin

Boss Baby (Ted) (voice)

Amy Sedaris

Tina (voice)

Ariana Greenblatt

Tabitha (voice)

Jeff Goldblum

Dr. Armstrong (voice)

Eva Longoria

Carol (voice)

James McGrath

Wizzie (voice)

Jimmy Kimmel

Grandpa (Ted Sr.) (voice)

Lisa Kudrow

Grandma (Janice) (voice)

Raphael Alejandro

Nathan / Lead Baby Ninja (voice)

Serenity Reign Brown

Meghan (voice)

David Soren

Jimbo (voice)